Bronopol Biyositinde Formaldehitsiz Mücadeleye Yönelik Stratejik Yaklaşım

Özet: To address the potential issue of free formaldehyde formation in Bronopol (BNP, CAS 52-51-7) biocides, it is essential to implement a comprehensive strategy that integrates process control, formulation optimization, and usage conditions. The following specific measures are recommended:

Anahtar Kelimeler: bronopol; BNP; biocide; preservative; CAS 52-51-7; C3H6BrNO4

1. Adjust the pH Value of the Formulation

Bronopol readily hydrolyzes into formaldehyde under alkaline conditions (pH > 8) or at elevated temperatures. By maintaining the pH of the formulation within a weakly acidic to neutral range (pH 5-7), the rate of hydrolysis can be significantly reduced.

2. Incorporate Stabilizers

Chelating Agents: Introduce EDTA (ethylenediaminetetraacetic acid) or sodium citrate to chelate metal ions such as iron and copper, thereby preventing these metals from catalyzing Bronopol decomposition.

Antioxidants: Add sulfites (e.g., sodium sulfite) or ascorbic acid (vitamin C) to inhibit oxidative side reactions.

3. Optimize Storage and Usage Conditions

Temperature Control: Store the product at temperatures below 25 °C and protect it from light exposure by using brown bottles or opaque packaging.

Minimize Exposure Time: Reduce the duration of open storage to minimize contact with air, thereby preventing moisture absorption and accelerating hydrolysis.

4. Purify Raw Materials

Strictly control the residual formaldehyde content during the synthesis of Bronopol.

5. Implement Low-Temperature Processing

Avoid high-temperature handling during the synthesis and preparation of Bronopol.

By adopting these integrated measures, Bronopol can effectively mitigate the risk of free formaldehyde formation while maintaining its bactericidal efficacy and ensuring compliance with safety standards.

Puyuan Pharm'daki Ar-Ge ekibi, çeşitli uygulamalar için endüstriyel sınıf brominole dayalı 12 özel Bronopol (BNP) türü geliştirdi. Gelişmiş kristalleştirme, rafinasyon, saflaştırma, yıkama, kurutma, bekletme ve serbest formaldehit kontrolü sayesinde bu ürünler daha yüksek saflık seviyelerine ulaşır. Üstün bakteri öldürücü, antiseptik, küf ve yosun öldürücü etkiler gösterir, kabarık kalır ve topaklanmaya karşı dirençlidir ve stabil bakteri öldürücü etkinliğini korur. Ek olarak, serbest formaldehit üzerindeki sıkı kontrol, çevre ve ürün güvenliğini sağlar.