Important insecticide intermediate of Dinotefuran ：N,O-dimethyl-N'-nitroisourea (MNO) 日本

Abstract: N,O-dimethyl-N'-nitroisourea (MNO, CAS: 255708-80-6), molecular formula: C3H7N3O3, relative molecular weight: 119.08, white crystal, melting point: 108 ~ 110 ℃, soluble in water and alcohol, often used in the preparation of nitroguanidine derivatives. As an important synthetic intermediate of dinotefuran, the demand of dinotefuran has increased rapidly in recent years.

Keywords:1,2-DIMETHYL-3-NITROISOUREA; N,O-Dimethyl-N'-nitroisourea; CAS: 255708-80-6; MNO; dinotefuran; insecticide;C3H7N3O3

N,O-dimethyl-N'-nitroisourea (MNO, CAS: 255708-80-6) is an organic compound. The following is an introduction to its nature, use, manufacturing and safety information:

1.Physical and chemical properties

1.1 Appearance: N,O-dimethyl-N'-nitroisourea (MNO, CAS: 255708-80-6) is a colorless crystalline solid.

1.2 Solubility: N,O-dimethyl-N'-nitroisourea (MNO, CAS: 255708-80-6) is slightly dissolved in water and has good solubility in most organic solvents.

1.3 Stability: N,O-dimethyl-N'-nitroisourea (MNO, CAS: 255708-80-6) is relatively stable at room temperature, but has a risk of explosion at high temperatures.

2.Scope of application

2.1 In machine synthesis, N,O-dimethyl-N'-nitroisourea (MNO, CAS: 255708-80-6) is used as a nitrification agent or in other forms.

2.2 In biochemical research, N,O-dimethyl-N'-nitroisourea (MNO, CAS: 255708-80-6) is also used as a selective metal ion trapping reagent.

3.Production method

3.1 Isourea is reacted with methyl bromide to produce methylisourea.

3.2 Reaction of methyl isourea with nitric acid to produce N,O-dimethyl-N'-nitroisourea.

4.Safety information

4.1N,O-dimethyl-N'-nitroisourea (MNO, CAS: 255708-80-6) is a potentially explosive compound and should be handled with care.

4.2 Take adequate personal protective measures when using, such as wearing chemical protective gloves and goggles.

4.3 Avoid contact with skin, eyes and respiratory tract. In case of contact, wash immediately with plenty of water.

4.4 It should be operated in a well-ventilated place, away from open flame and heat source.

4.5 Do not inhale dust or gases and avoid ingestion or swallowing.

4.6 Should be stored properly, away from inorganic substances, oxidants and inflammables.

Before using N,O-dimethyl-N'-nitroisourea (MNO, CAS: 255708-80-6), please be sure to consult the relevant safety information and operate according to the formal experimental procedures.