Application of isothiazolinones as preservatives

Abstract: Isothiazolinone preservatives are biocidal products with isothiazolinone derivatives as the main active ingredients. Common isothiazolinone derivatives include OIT(2-Octyl-2H-isothiazol-3-one, CAS: 26530-20-1), DCOIT (4,5-Dichloro-2-octyl-isothiazolone, CAS: 64359-81-5), etc. Such biocides are internationally recognized as high-efficiency, low-toxicity, broad-spectrum green biocides..

Keywords: fungicide; biocide; mildewproof agent; preservative; OIT;2-Octyl-2H-isothiazol-3-one; isothiazolin;26530-20-1;DCOIT;4,5-Dichloro-2-octyl-isothiazolone; 64359-81-5

The production process and product preservation in many industrial fields have an indispensable demand for sterilization, bacteriostasis, corrosion prevention and mildew prevention. Isothiazolinone products have become one of the mainstream industrial non-oxidizing fungicides with their excellent characteristics such as small amount, broad spectrum, long effect period and green environmental protection.

1.Industrial water treatment

In the industrial circulating water system, due to the continuous evaporation and concentration of water, material leakage and appropriate water temperature, resulting in a large number of bacteria, algae and fungi, and the attachment of biological mud on the heat exchange equipment will seriously affect the heat exchange efficiency, while microorganisms will also corrode the equipment and pipelines, thus affecting the operation of the entire system, and even lead to production suspension. There are many kinds of fungicides used to control industrial water, and there are differences in performance, and a single product is difficult to kill all harmful microorganisms, so it is generally used in combination with several products, isothiazolinone products are one of the mainstream non-oxidized fungicides, such as OIT(2-Octyl-2H-isothiazol-3-one, CAS: 26530-20-1) and DCOIT (4,5-Dichloro-2-octyl-isothiazolone, CAS: 64359-81-5).

2.Paper industry

Pulp and paint in the papermaking process are easy to breed microorganisms, a large number of reproduction will produce broken paper, resulting in stains on the paper, black spots and holes and other paper diseases, resulting in additives, paint deterioration, resulting in paper discoloration, blocking mesh, paper machine system and paper products produce odor and many other negative effects. Therefore, pulping, coating and white water recycling in the paper mill production process require a large amount of preservatives, and the paper has mildew protection requirements. A good paper industry fungicide should not only have high efficiency, low toxicity, broad spectrum and other properties, but also no odor, does not affect the color of the paper, good self-biodegradation, long-term use does not pollute the environment, PH≤9 does not decompose failure, isothiazolinone derivatives meet these conditions (OIT, DCOIT), It can be used for sterilization and anticorrosion of slurry, and can also be used for sterilization and anticorrosion of paint, and is generally used in combination with other products in practice.

3.Coating anticorrosion

Isothiazolinone fungicides used for coating corrosion protection have the characteristics of small dosage, long duration and environmental friendliness, and have gradually become a substitute for formaldehyde fungicides. OIT(2-Octyl-2H-isothiazol-3-one, CAS: 26530-20-1) has good anti-mildew effect on water-based paint, good weather resistance, and is suitable for anti-mildew of external wall paint. DCOIT (4,5-Dichloro-2-octyl-isothiazolone, CAS: 64359-81-5) is mainly used in Marine paint in the United States, and has a good effect on inhibiting the growth of algae in the hull.

4.Daily chemical industry

Personal care products and cosmetics contain nutrients such as water and protein, most of which are reused many times after opening, so it is easier to pollute microorganisms and lead to spoilage. The deterioration of the product will produce odor, stratification, discoloration and mildew and other phenomena, causing harm to the health of consumers, but also make the product lose the value of use. Therefore, daily chemical products in the production process must be strictly controlled to prevent the generation of bacteria, and consumers in the use and storage process is also facing the problem of secondary pollution, so it is necessary to add appropriate preservatives to inhibit the reproduction of microorganisms, and the safety and stability of preservatives is crucial. Isothiazolinone products used for anti-corrosion of daily chemical products have the characteristics of good compatibility, broad spectrum efficiency, low toxicity, environmental safety, long period of validity and so on. The use of mass fraction within 0.03%-0.1% has a good antibacterial and bactericidal effect, can be used in cream, lotion, shampoo, hair care agent, children's and eye cosmetics.