Analysis of anti-mildew and antibacterial mechanism of isothiazolinone series products OIT(CAS：26530-20-1)

Abstract:Isothiazolinone derivatives refers to a series of compounds containing isothiazolinone ring, is a new class of broad-spectrum high-efficiency non-oxidizing bactericides, especially OIT (CAS：26530-20-1) and DCOIT(CAS:64359-81-5), because of its high efficiency, environmental friendliness and broad spectrum advantages, so widely used in industrial circulating cooling water, adhesives, textiles, coatings, emulsions, plastics, paper and other fields.

Keywords:OIT;2-Octyl-2H-isothiazol-3-one;isothiazolinone;CAS:26530-20-1;anti-mildew;antibacterial

1.Product overview

1.1,OIT(2-Octyl-2H-isothiazol-3-one),molecular weight: 213.34,CAS: 26530-20-1, molecular formula: C11H19NOS.

1.2,OIT(2-Octyl-2H-isothiazol-3-one,CAS:26530-20-1) fungicide is an environmentally friendly, efficient, broad-spectrum, non-formaldehyde-releasing dry film anti-mildew agent. OIT fungicide has a strong killing effect on molds, yeasts, bacteria and fungi, and its anti-mildew property can reach grade 0(super grade anti-mildew) in line with EU standards. The anti-mildew performance has been tested by relevant authorities, and it is a new generation of world-class bactericidal anti-mildew agent.

2.Performance characteristics

2.1,OIT(2-Octyl-2H-isothiazol-3-one,CAS:26530-20-1) fungicide has a strong ability to kill mold, a wide range of use, is the replacement of traditional paint film mildew prevention agents.

2.2, Low toxicity, easy to operate, can be added in any process.

2.3,The applicable pH range is wide, 3 ~ 9 can be used.

2.4, Uniform dispersion, no VOC, heat stability.

2.5, Does not accumulate in the environment, easy to degrade.

2.6, Stable under strong ultraviolet and acid rain conditions.

2.7, As long as five years of outdoor weather resistance experiment results proved that the effect is good.

3.Mechanism analysis

The biological activity of isothiazolinones is based on their extremely strong penetration of the receptor cell membrane and cell wall, and then interaction with the cell's sulfur-containing proteins, enzymes or simple molecules causes their S-N bonds to break and form S-S bonds with the receptor, thus disrupting the normal function of the cell. After contact with microorganisms, it can rapidly and irreversibly inhibit their growth, resulting in the death of microbial cells.

4.Specific indicators

5.Application field

OIT(2-Octyl-2H-isothiazol-3-one,CAS:26530-20-1) fungicide is widely used in: paint, coatings, industrial oil, plastics, building materials, leather, water emulsion, glue, textile printing and dyeing fields of anti-mildew. It can also be widely used in interior and exterior latex paint, wood products and cultural relics protection and many other products.

6.Usage and dosage

OIT(2-Octyl-2H-isothiazol-3-one,CAS:26530-20-1) fungicide recommended concentration of 0.1 ~ 0.5%, the amount of use depends on the actual situation. This product is used in the field of sterilization and mildew prevention of interior and exterior latex paint, the recommended amount of addition is 0.1 ~ 0.3%, the specific amount depends on the performance of the coating product and the use environment.

7.Note

OIT(2-Octyl-2H-isothiazol-3-one,CAS:26530-20-1) fungicide is liquid at room temperature, crystal at low temperature, soluble in organic solvents, slightly soluble in water.If it is splashed on the skin, wash it with water in time to avoid allergies or burns.OIT fungicide should be used in the medium with pH ≤ 9.5.Wear protective clothing, rubber gloves and eye masks to avoid contact with skin, eyes and mucous membranes.

8.Properties of isothiazolinones and their derivatives

8.1,OIT(2-Octyl-2H-isothiazol-3-one,CAS:26530-20-1)fungicide, the appearance of the commodity is generally light yellow to colorless transparent liquid. The product has an antibacterial effect on most microorganisms, especially on mold has a strong killing ability.Advantages: Good color stability, pH

8.2,DCOIT(4,5-Dichloro-2-octyl-isothiazolone,CAS:64359-81-5), the appearance of white powder. The product belongs to the new generation of environmentally friendly mildew and algae repellent, and won the President's Green Chemistry Award from the US Environmental Protection Agency for its excellent environmental friendliness.