Abstract: Isothiazolinone derivatives are the general name of a series of compounds containing isothiazolinone rings. They are a new class of broad-spectrum and high-efficiency non-oxidizing fungicides, due to their advantages of high efficiency, environmental friendliness and broad spectrum. Therefore, it is widely used in industrial circulating cooling water, adhesives, textiles, coatings, emulsions, plastics, paper and other fields.

Keywords: fungicide; isothiazolin;OIT;2-Octyl-2H-isothiazol-3-one; 26530-20-1;DCOIT;4,5-Dichloro-2-octyl-isothiazolone; 64359-81-5

1.Bactericidal mechanism

The biological activity of isothiazolinone is based on their extremely strong penetration of the receptor cell membrane and cell wall, and then interaction with the cell's sulfur-containing proteins, enzymes or simple molecules causes their S-N bonds to break and form S-S bonds with the receptor, thus disrupting the normal function of the cell. After contact with microorganisms, it can rapidly and irreversibly inhibit their growth, resulting in the death of microbial cells.

2.Application of isothiazolinone fungicides

Paper industry: isothiazolinone industrial fungicides can be applied in the paper making process, play a bactericidal and antibacterial role in the pulp and paper machine and other links, effectively control the breeding and growth of microorganisms, thereby improving the quality and production efficiency of paper.

Paint and coatings industry: isothiazolinone industrial fungicides can be applied in paint and coatings production to control the breeding and reproduction of microorganisms in paint, avoid problems such as corruption, deterioration, discoloration, and so on, thereby enhancing the shelf life and stability of paint.

Plastics industry: isothiazolinone industrial fungicides can be applied to the plastic production process to control the microbial pollution on the surface of plastic molds and inside plastic products, avoid product deterioration, deterioration and other problems, so as to improve the quality and service life of plastic products.

Leather industry: isothiazolinone industrial fungicides can be applied to leather production, play a bactericidal and anti-corrosion role in the entire processing process, avoid production problems caused by microbial pollution, thereby improving the quality and shelf life of leather.

3.Isothiazolinone fungicide products

At present, the main products of isothiazolinone fungicide on the market are OIT(2-Octyl-2H-isothiazol-3-one, CAS: 26530-20-1) and DCOIT(4,5-Dichloro-2-octyl-isothiazolone, CAS: 64359-81-5).

OIT is an environmentally friendly, efficient, broad-spectrum, non-formaldehyde-releasing dry film anti-mildew agent. OIT fungicide has a strong killing effect on molds, yeasts, bacteria and fungi, and its anti-mildew property can reach grade 0(super grade anti-mildew) in line with EU standards. The anti-mildew performance has been tested by relevant authorities, and it is a new generation of world-class bactericidal anti-mildew agent. OIT is widely used in: paint, coatings, industrial oil, plastics, building materials, leather, water emulsion, glue, textile printing and dyeing fields of anti-mildew. It can also be widely used in interior and exterior latex paint, wood products and cultural relics protection and many other products.

The appearance of DCOIT is white powder. The product belongs to the new generation of environmentally friendly mildew and algae repellent. DCOIT can be widely used in polyethylene, polyurethane, leather, paint, coatings, sewage, paper, wood, adhesives, ink and other fields. It can replace compounds such as toxic organoarsenic.

4.Safety protection

Isothiazolinone fungicide is corrosive and irritating to the skin and eyes. It should be equipped with protective glasses and rubber gloves when operating. Once it comes into contact with the skin and eyes, it should be washed with plenty of water immediately. In case of contact with skin, immediately remove contaminated clothes and shoes, rinse with plenty of water for at least 15 minutes, apply urea acetate ointment or burn ointment to the affected area, and seek medical attention immediately.

5.Sum up

In general, isothiazolinone industrial fungicides have a wide range of applications and good bactericidal effect. Of course, in the process of use, it is necessary to understand its applicable conditions and use methods to ensure safe and effective control of microbial pollution. At the same time, the application must also comply with the relevant safety guide and environmental protection requirements.